ChemicalBook CAS DataBase List ICI D2138

ICI D2138 synthesis

6synthesis methods

Product Name:ICI D2138
CAS Number:140841-32-3
Molecular formula:C23H24FNO4
Molecular Weight:397.44

29943-42-8 Synthesis

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Yield:-

Steps:

Multi-step reaction with 4 steps
1: 1.) n-BuLi / 1.) THF, hexane, -70 deg C, 1 h, 2.) THF, hexane, from -70 to 0 deg C, 3 h
2: 1.) NaH / 1.) DMF, 5 deg C, 1 h, 2.) DMF, from 5 deg C to RT, overnight
3: 95 percent / H₂ / 10percent Pd/C / ethanol / 2 h
4: 88 percent / K₂CO₃ / dimethylformamide / Ambient temperature

References:

Crawley;Dowell;Edwards;Foster;McMillan;Walker;Waterson [Journal of Medicinal Chemistry,1992,vol. 35,# 14,p. 2600 - 2609]