IFLAB-BB F0017-0358 synthesis

Yield:24966-91-4 85%

Reaction Conditions:

in water; for 0.166667 h;Sonication;

Steps:

General Procedure for the Preparation of Compounds4a-g and 5a-g in Water

General procedure: Corresponding 2-bromoacetophenones 1a-g (199-278 mg; 1mmol), thiourea 2 (91.2 mg; 1.2 mmol) or selenourea 3 (147 mg; 1.2 mmol) and 5 mL of water were added to a round bottom flask and reactions proceeded under ultrasonic irradiation in a Multiwave Eco-sonics QR750 ultrasonic generator (20 kHz, 750 W) equipped with a converter/transducer, and titanium oscillator (horn, diameter = 4 mm) for 10 minutes. Afterwards, the mixture was cooled down and the products were filtered and washed with 1 mL of water, furnishing the desired thiazoles or selenazoles.

References:

Facchinetti, Victor;de Souza, Marcus V. N.;Nery, Ana C. S.;Calixto, Stephane L.;Granato, Juliana T.;Coimbra, Elaine S.;Louren?o, Maria C. S.;Gomes, Claudia R. B.;Vasconcelos, Thatyana R. A. [Letters in drug design and discovery,2018,vol. 15,# 11,p. 1224 - 1229]