![](/CAS/GIF/151271-08-8.gif)
imidazenil synthesis
- Product Name:imidazenil
- CAS Number:151271-08-8
- Molecular formula:C18H12BrFN4O
- Molecular Weight:399.22
A mixture of 3 g (7.5 mmol) of 6-(2-bromophenyl)-8-fluoro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, 300 mL of methylene chloride and 2.25 g (10.8 mmol) of phosphorus pentachloride was stirred at room temperature for 2 hours. Ammonia gas was then introduced until the mixture was basic. After layering with 20 mL of concentrated aqueous ammonia, the mixture was stirred for 15 minutes. The methylene chloride was washed with water, dried and evaporated. The residue was crystallized from ethanol/water to yield 2.4 g of product having the above formula. A second crop of 0.4 g was obtained from the mother liquor for a total yield of 2.8 g. For analysis, a sample of the product was recrystallized from methylene chloride/ethanol and had m.p. 298°-299° C.
![synthesis of imidazenil.png synthesis of imidazenil.png](/NewsImg/2022-12-08/6380611151827950635947587.jpg)
![4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, 6-(2-bromophenyl)-8-fluoro-](/CAS/20210111/GIF/153874-00-1.gif)
153874-00-1
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![imidazenil](/CAS/GIF/151271-08-8.gif)
151271-08-8
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$455.06/5MG
Yield:-
Reaction Conditions:
with phosphorus pentachloride;ammonia in dichloromethane;
Steps:
9 6-(2-Bromophenyl)-8-fluoro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxamide
EXAMPLE 9 6-(2-Bromophenyl)-8-fluoro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxamide A mixture of 3 g (7.5 mmol) of 6-(2-bromophenyl)-8-fluoro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, 300 mL of methylene chloride and 2.25 g (10.8 mmol) of phosphorus pentachloride was stirred at room temperature for 2 hours. Ammonia gas was then introduced until the mixture was basic. After layering with 20 mL of concentrated aqueous ammonia, the mixture was stirred for 15 minutes. The methylene chloride was washed with water, dried and evaporated. The residue was crystallized from ethanol/water to yield 2.4 g of product having the above formula. A second crop of 0.4 g was obtained from the mother liquor for a total yield of 2.8 g. For analysis, a sample of the product was recrystallized from methylene chloride/ethanol and had m.p. 298°-299° C.
References:
US5317018,1994,A
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![imidazenil](/CAS/GIF/151271-08-8.gif)
151271-08-8
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$455.06/5MG
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151271-08-8
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$455.06/5MG
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151271-08-8
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$455.06/5MG
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153873-99-5
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![imidazenil](/CAS/GIF/151271-08-8.gif)
151271-08-8
38 suppliers
$455.06/5MG