ChemicalBook CAS DataBase List imidazo[1,2-a]pyridin-8-ylmethan amine

imidazo[1,2-a]pyridin-8-ylmethan amine synthesis

2synthesis methods

Product Name:imidazo[1,2-a]pyridin-8-ylmethan amine
CAS Number:933721-91-6
Molecular formula:C8H9N3
Molecular Weight:147.18

136117-70-9
35 suppliers
inquiry

933721-91-6
21 suppliers
inquiry

Yield:933721-91-6 100%

Reaction Conditions:

with ammonium hydroxide;hydrogen in methanol at 20;

Steps:

4 Example 4: Imidazo[l,2-a]pyridin-8-ylmethanamine

[0545] To a solution of imidazo[l,2-a]pyridine-8-carbonitrile (1 equiv.) in methanol and aq. ammonia solution (9: 1), catalytic amount of Raney Nickel was added. Reaction mass was stirred at room temperature under hydrogen pressure (balloon pressure) for 2-5 h. On completion of reaction, it was filtered through celite bed and filtrate was concentrated under reduce pressure to afford respective amines (quantitative yield).

References:

WO2014/144747,2014,A1 Location in patent:Paragraph 0545

24517-64-4 Synthesis

24517-64-4
232 suppliers
$9.00/1g

933721-91-6
21 suppliers
inquiry

References