Imidazol-1-yl-morpholin-4-yl-methanone synthesis
- Product Name:Imidazol-1-yl-morpholin-4-yl-methanone
- CAS Number:93605-74-4
- Molecular formula:C8H11N3O2
- Molecular Weight:181.19
Yield:93605-74-4 90.62%
Reaction Conditions:
in dichloromethane at 20;
Steps:
1.3 Synthesis of N-imidazole-4-morpholine formamide
Room temperature, CDI 16.21 g and 80 mL of dichloromethane were added to a 250 mL three-necked flask, Stir, Constant pressure dropping 8.7 g of morpholine Dichloromethane (50 mL)Dropwise for about 1 hour, Room temperature to continue reaction 5 to 6 hours; After completion of the reaction, 60 mL of water was added, The aqueous layer was extracted with dichloromethane (50 mL x 3) Combined organic layer, 5 g of anhydrous sodium sulfate was added for 3 hours, filter, Concentrated to give 16.42 g of a white solid N-imidazole-4-morpholine formamide, The yield was 90.62%.
References:
CN106608863,2017,A Location in patent:Paragraph 0080; 0093; 0108; 0123
