![](/CAS/GIF/1201-26-9.gif)
Indole-3-acetone synthesis
- Product Name:Indole-3-acetone
- CAS Number:1201-26-9
- Molecular formula:C11H11NO
- Molecular Weight:173.21
![Methylmagnesium Bromide](/CAS/GIF/75-16-1.gif)
75-16-1
264 suppliers
$12.00/10ml
![2-(1H-indol-3-yl)-N-Methoxy-N-MethylacetaMide](/CAS/20150408/GIF/132922-37-3.gif)
132922-37-3
29 suppliers
$45.00/10mg
![Indole-3-acetone](/CAS/GIF/1201-26-9.gif)
1201-26-9
135 suppliers
$80.00/250mg
Yield:1201-26-9 2.35 g
Reaction Conditions:
in tetrahydrofuran at 0; for 5 h;
Steps:
a Intermediate 20. 6-Bromo-8-iodo-1,3-dimethyl-9H-pyrido[3,4-b]indole
a) 1-(1H-Indol-3-yl)propan-2-one Under argon 2-(1H-indol-3-yl)-N-methoxy-N-methylacetamide (3.00 g, 13.75mmol) was dissolved in THF (60 ml) and the solution cooled to 0 °C. A methylmagnesium bromide solution in THF(27.49 ml, 27.49 mmol) was slowly added with stirring. After 2 h a second portion of methylmagnesium bromidesolution (27.49 ml, 27.49 mmol) and after 3 h a third portion of methylmagnesium bromide solution (27.49 ml, 27.49mmol) were added. Then an aqueous ammonium chloride solution was added, followed by EA. The phases wereseparated, and the organic phase was washed with water and brine, dried, filtered and concentrated in vacuo. Theresidue was purified by chromatography over silica gel with HEP/EA (gradient) to yield 2.35 g of the title compound.LC/MS (Method LC5): RT = 1.56 min; m/z = 174.1 [M+H]+
References:
EP3318563,2018,A1 Location in patent:Paragraph 0155
![1H-Indole, 3-(2-nitropropyl)-](/CAS/20180601/GIF/4771-72-6.gif)
4771-72-6
1 suppliers
inquiry
![Indole-3-acetone](/CAS/GIF/1201-26-9.gif)
1201-26-9
135 suppliers
$80.00/250mg
![3-Methylindole](/CAS/GIF/83-34-1.gif)
83-34-1
479 suppliers
$12.00/10g
![Acetyl chloride](/CAS/GIF/75-36-5.gif)
75-36-5
561 suppliers
$17.92/100G
![Indole-3-acetone](/CAS/GIF/1201-26-9.gif)
1201-26-9
135 suppliers
$80.00/250mg
![Ethanone, 1,1'-(3-methyl-1H-indole-2,5-diyl)bis- (9CI)](/CAS/20210305/GIF/16244-29-4.gif)
16244-29-4
0 suppliers
inquiry
![Methylmagnesium chloride](/CAS/GIF/676-58-4.gif)
676-58-4
278 suppliers
$15.00/25ml
![2-(1H-indol-3-yl)-N-Methoxy-N-MethylacetaMide](/CAS/20150408/GIF/132922-37-3.gif)
132922-37-3
29 suppliers
$45.00/10mg
![Indole-3-acetone](/CAS/GIF/1201-26-9.gif)
1201-26-9
135 suppliers
$80.00/250mg
![1H-Indole, 3-[(1Z)-2-nitro-1-propen-1-yl]-](/CAS/20210305/GIF/84584-89-4.gif)
84584-89-4
1 suppliers
inquiry
![Indole-3-acetone](/CAS/GIF/1201-26-9.gif)
1201-26-9
135 suppliers
$80.00/250mg