INO5042 synthesis

Yield:14782-19-5 60 %

Reaction Conditions:

with sulfur;potassium carbonate in N,N-dimethyl acetamide at 110;

Steps:

16 Example 16

Add 2-amino-1,4-naphthoquinone (0.0346 g, 0.20 mmol), 2-furancarboxaldehyde (0.0230 g, 0.24 mmol),_S8(0.1534 g, 0.60 mmol), and_K2CO3to a 25 mL reaction tube (0.0276 g, 0.20 mmol) with 1 mL of DMA as solvent, then stirred at 110 °C for 4 h. After the end of the reaction by TLC detection, the reaction solution was cooled to room temperature, 30mL of water was added, extracted with ethyl acetate (3×10mL), the organic phase was combined, the solvent was removed by rotary evaporation after drying by anhydrous sodium sulfate, and finally column chromatographic separation (the eluent is a mixture of petroleum ether and dichloromethane, V petroleum ether/V dichloromethane = 2/1) to obtain a target compound with a yield of 60%, which is a red solid and its chemical structure formula is:

References:

CN115286594,2022,A Location in patent:Paragraph 0060-0062