Isobutanesulfonyl chloride synthesis
- Product Name:Isobutanesulfonyl chloride
- CAS Number:35432-36-1
- Molecular formula:C4H9ClO2S
- Molecular Weight:156.63
513-44-0
146 suppliers
$21.00/5mL
35432-36-1
92 suppliers
$22.80/250mg
Yield:35432-36-1 95%
Reaction Conditions:
Stage #1:2-methylpropanethiol-1 with sulfuryl dichloride;potassium nitrate in acetonitrile at 0; for 3 h;
Stage #2: with sodium hydrogencarbonate in water;acetonitrile
Steps:
2-Methyl-1-propanesulfonyl chloride
To [2-METHYL-1-PROPANETHIOL] (200 mg, 2.22 mmol) at [0C] in acetonitrile under nitrogen was added [KNOWS] (561 mg, 5.5 mmol) then sulfuryl chloride (0.45 ml, 5.5 mmol). The reaction mixture was stirred at [0C] for 3h, diluted with [NAHCO3] and extracted with ethyl acetate. The combined organic layers were washed with brine, dried [(MGS04)] and evaporated to give the sulfonyl chloride (293 mg, 95%)
References:
MERCK SHARP & DOHME LIMITED WO2004/31139, 2004, A1 Location in patent:Page 19
1518-72-5
81 suppliers
$45.00/250mg
35432-36-1
92 suppliers
$22.80/250mg
591-84-4
1 suppliers
inquiry
35432-36-1
92 suppliers
$22.80/250mg
27846-15-7
0 suppliers
inquiry
35432-36-1
92 suppliers
$22.80/250mg
75-28-5
122 suppliers
$40.00/1g
35432-36-1
92 suppliers
$22.80/250mg