ChemicalBook CAS DataBase List Isocarbostyril

Isocarbostyril synthesis

9synthesis methods

Product Name:Isocarbostyril
CAS Number:491-30-5
Molecular formula:C9H7NO
Molecular Weight:145.16

19493-44-8 Synthesis

19493-44-8
254 suppliers
$6.00/1g

491-30-5
261 suppliers
$7.00/250mg

Yield:491-30-5 80%

Reaction Conditions:

with ammonium acetate;acetic acid at 100; for 3 h;

Steps:

11.3 Step 3: isoquinolin-1 (2H)-one
A solution of 1 -chloroisoquinoline (8.1 g) in glacial acetic acid (170 mL) was treated with ammonium acetate (25 g). The reaction mixture was then heated at 100 °C for 3h. The reaction mixture was cooled to room temperature and the solvent was evaporated under reduced pressure. The residue was quenched with ice and the solid formed was filtered and dried on the filter (5.8 g, 80%). 1H NMR (400 MHz, DMSO-d6): δ 1 1.24 (s, 1 H), 8.18 (d, J= 8.4 Hz, 1 H), 7.63-7.71 (m, 2H), 7.45-7.49 (m, 1 H), 7.15-7.18 (m, 1 H), 6.55 (d, J= 7.2 Hz, 1 H). MS (ESI+): 146.0, HPLC (Method A) Rt 2.23min; HPLC purity 98.2 %

References:

ARES TRADING S.A.;SWINNEN, Dominique;MORANDI, Federica WO2013/92979, 2013, A1 Location in patent:Page/Page column 54

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