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ChemicalBook CAS DataBase List ISONICOTINE

ISONICOTINE synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: i-Pr2NEt, LiCl, P(2-furyl)3 / Pd(OAc)2 / dimethylformamide / 100 °C
2: HCO2NH4 / Pd/C / methanol / 4 h / Heating
3: LiAlH4 / diethyl ether / 2 h / Heating

References:

Sonesson, Clas;Wikstroem, Hakan;Smith, Martin W.;Svensson, Kjell;Carlsson, Arvid;Waters, Nicholas [Bioorganic and Medicinal Chemistry Letters,1997,vol. 7,# 3,p. 241 - 246]