Isopropyl 1H-imidazole-1-carboxylate synthesis
- Product Name:Isopropyl 1H-imidazole-1-carboxylate
- CAS Number:82998-18-3
- Molecular formula:C7H10N2O2
- Molecular Weight:154.17
Step 1: Imidazole- 1-carboxylic acid isopropyl ester; To a solution of CDI (2 g, 12.33 mmol), in DCM (25 mL) was added isopropyl alcohol (0.95 mL, 12.33 mmol) at 0 0C. The reaction mixture was stirred at r.t. and progress of the reaction was monitored by TLC. On completion, the reaction mixture was diluted with DCM (100 mL). The organic layer was washed with water (25 mL), brine (25 mL), dried over anhydrous sodium sulphate and concentrated in vacuo. The residue was purified by column chromatography (silica gel, 1: 10 ethyl acetate:Pet. ether) to provide Isopropyl 1H-imidazole-1-carboxylate (330 mg, 77%) as colourless viscous oil. ESIMS (m/z): 155.1 (M+ 1).
67-63-0
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530-62-1
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82998-18-3
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$79.79/5g
Yield:82998-18-3 77%
Reaction Conditions:
in dichloromethane at 0 - 20;
Steps:
V.1
Example V- {3-[3,5-Difluoro-4-(4-{2-[( pyridine-3-carbonyl)-aminoJ-acetyl}- piperazin-l-yl)-phenyl]-2-oxo-oxazolidin-(5S)-ylmethyl}-carbamic acid isopropyl ester; Step 1: Imidazole- 1-carboxylic acid isopropyl ester; To a solution of CDI (2 g, 12.33 mmol), in DCM (25 mL) was added isopropyl alcohol (0.95 mL, 12.33 mmol) at 0 0C. The reaction mixture was stirred at r.t. and progress of the reaction was monitored by TLC. On completion, the reaction mixture was diluted with DCM (100 mL). The organic layer was washed with water (25 mL), brine (25 mL), dried over anhydrous sodium sulphate and concentrated in vacuo. The residue was purified by column chromatography (silica gel, 1: 10 ethyl acetate:Pet. ether) to provide title compound (330 mg, 77%) as colourless viscous oil. ESIMS (m/z): 155.1 (M+ 1)
References:
WO2010/58423,2010,A2 Location in patent:Page/Page column 57-58
288-32-4
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108-23-6
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82998-18-3
12 suppliers
$79.79/5g