ChemicalBook CAS DataBase List KS-99

KS-99 synthesis

3synthesis methods

Product Name:KS-99
CAS Number:1344698-28-7
Molecular formula:C17H10Br2N2O2S
Molecular Weight:466.15

1H-Indole-2,3-dione, 5,7-dibromo-1-[[4-(bromomethyl)phenyl]methyl]-

1344698-26-5
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333-20-0
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1344698-28-7
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Yield:1344698-28-7 74%

Reaction Conditions:

with potassium iodide in acetonitrile at 20;

Steps:

4.1.2. 5,7-Dibromo-N-(3’-thiocyanatopropyl)isatin (4)

General procedure: Compound 3 (200 mg, 0.52 mmol) was dissolved in anhydrous acetonitrile (15 mL), and KI (300 mg, 1.81 mmol) and KSCN (200 mg, 2.05 mmol) were added. The mixture was stirred overnight until a substantial amount of product was formed. The reaction mixture was diluted with water and extracted with ethyl acetate (3 × 50 mL). The organic layer was washed with water, dried over anhydrous MgSO₄, and evaporated to dryness on the rotary evaporator. The crude product was purified by silica gel column chromatography (CH₂Cl₂-hexane, 7:3) eluted the product 4 as a yellow-orange solid (140 mg, 65%).

References:

Krishnegowda, Gowdahalli;Prakasha Gowda;Tagaram, Hephzibah Rani S.;Carroll, Kevin F. Staveley-O;Irby, Rosalyn B.;Sharma, Arun K.;Amin, Shantu [Bioorganic and Medicinal Chemistry,2011,vol. 19,# 20,p. 6006 - 6014] Location in patent:experimental part

6374-91-0 Synthesis

6374-91-0
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1344698-28-7
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References

91-56-5 Synthesis

91-56-5
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1344698-28-7
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References