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ChemicalBook CAS DataBase List L-701,252
151057-13-5

L-701,252 synthesis

2synthesis methods
60064-34-8 Synthesis
Ethyl 2-amino-4-chlorobenzoate

60064-34-8
24 suppliers
$45.00/100mg

-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: 99 percent / Et3N / tetrahydrofuran; toluene / -5 - 20 °C
2: 1.) LiHMDS / 1.) THF, -78-0 deg C, 30 min, 2.) THF, a.) -78 deg, 30 min, b.) -78 deg C - RT, 2 h
3: NaOMe / methanol / 18 h / Heating

References:

Rowley, Michael;Leeson, Paul D.;Stevenson, Graeme I.;Moseley, Angela M.;Stansfield, Ian;et al. [Journal of Medicinal Chemistry,1993,vol. 36,# 22,p. 3386 - 3396]

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