ChemicalBook CAS DataBase List L-Acetylcarnitine

L-Acetylcarnitine synthesis

6synthesis methods

Product Name:L-Acetylcarnitine
CAS Number:3040-38-8
Molecular formula:C9H17NO4
Molecular Weight:203.24

541-15-1 Synthesis

541-15-1
920 suppliers
$5.00/5g

75-36-5 Synthesis

75-36-5
561 suppliers
$17.92/100G

3040-38-8
44 suppliers
$638.98/1G

Yield:3040-38-8 71.4%

Reaction Conditions:

with triethylamine in dichloromethane at 0 - 5; for 12 h;Concentration;

Steps:

1 Example 1
Equipped with a mechanical stirrer and thermometer, a three-necked flask was filled with 100 g of L-carnitine zwitterion (0.62 mol, 1 eq), dichloromethane 3 liters, and 188.2 g of triethylamine (1.86 mol, 3.0 eq). Stirring down to 0 ~ 5°C. 97.34 g of acetyl chloride (1.24 mol, 2.0 eq) was added dropwise. After dropping, the reaction was carried out at 0 to 5°C for 12 hours then filtered. The filter cake was washed with dichloromethane to obtain crude acetyl-L-carnitine. This was dissolved in an appropriate amount of ethanol. Stirring dissolved. The solid was then precipitated by the addition of acetone and filtered. The filter cake was washed with acetone. Vacuum drying to obtain refined products 90 grams, yield 71.4%, purity 99.6%. Nuclear magnetic resonance spectrum shown in Figure 1. The mass spectrum is shown in Figure 2.

References:

Guangdong Longfu Pharmaceutical Co. Ltd.;Zhang, Longxin;Zhang, Shengbin;Ou, Guanlin CN105732407, 2016, A Location in patent:Paragraph 0008; 0009

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