L-ERYTHRO-4-FLUOROGLUTAMIC ACID synthesis

11synthesis methods

Product Name:L-ERYTHRO-4-FLUOROGLUTAMIC ACID
CAS Number:32563-24-9
Molecular formula:C5H8FNO4
Molecular Weight:165.12

L-Proline, 4-fluoro-5-oxo-, methyl ester, (4R)- (9CI)

393810-25-8
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32563-24-9
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Yield:32563-24-9 60%

Reaction Conditions:

Stage #1: (2S,4R)-4-fluoro-5-oxo-pyrrolidine-2-carboxylic acid methyl esterwith hydrogenchloride in water; for 4 h;Heating;
Stage #2: with methyloxirane in ethanol at 0; for 0.333333 h;Further stages.;

References:

Konas;Coward [Journal of Organic Chemistry,2001,vol. 66,# 26,p. 8831 - 8842]

L-Proline, 1-acetyl-4-hydroxy-, methyl ester, (4S)-

78804-96-3
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32563-24-9
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L-Proline, 1-acetyl-4-fluoro-5-oxo-, methyl ester, trans- (9CI)

149033-38-5
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32563-24-9
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References

L-Proline, 1-acetyl-4-fluoro-, methyl ester, (4R)-

132651-95-7
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32563-24-9
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L-Proline, 1-acetyl-4-hydroxy-, methyl ester, (4R)-

67943-19-5
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32563-24-9
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References