![](/CAS/GIF/14073-97-3.gif)
L-MENTHONE synthesis
- Product Name:L-MENTHONE
- CAS Number:14073-97-3
- Molecular formula:C10H18O
- Molecular Weight:154.25
![Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1R)-](/CAS/20210305/GIF/904840-84-2.gif)
904840-84-2
0 suppliers
inquiry
![L-MENTHONE](/CAS/GIF/14073-97-3.gif)
14073-97-3
269 suppliers
$14.00/1g
Yield:14073-97-3 836 g
Reaction Conditions:
with Dess-Martin periodane in dichloromethane at 20; for 16 h;Inert atmosphere;
Steps:
Intermediate 1 : L-menthone
Three batches of the same reaction were carried out in parallel. To a solution of (R)-menthol (300g) in DCM (2.7M) was added Dess-martin reagent (1.1 Oeq) at 20°C under N2. The reaction was stirred at 20°C for 16 hrs. The three reactions were combined for workup. The resulting mixture was poured into water (4.3V). The aqueous phase was extracted with DCM (1.4V x 3). The combined organic phases were washed with a saturated aqueous solution of Na2SC>3 (1.4V x 2). The organic phase was checked by potassium iodidestarch test paper: the test paper did not change to blue. The organic phase was washed with brine (1.4V x 2), dried with anhydrous Na2SO4, filtered and concentrated under vacuum. The residue was purified by flash chromatography with petroleum ether & ethyl acetate to give L-menthone (836g) as colorless oil. 1H NMR: 400 MHz DMSO-cfe (8 ppm): 1.98-2.18 (m, 5H), 1.72-1.86 (m, 2H), 1.24-1.40 (m, 2H), 0.95 (d, J = 6.4 Hz, 3H), 0.85 (d, J = 6.8 Hz, 3H), 0.79 (d, J = 6.8 Hz, 3H).
References:
WO2022/133027,2022,A1 Location in patent:Page/Page column 65
![L-Menthol](/CAS/GIF/2216-51-5.gif)
2216-51-5
664 suppliers
$5.00/100mg
![L-MENTHONE](/CAS/GIF/14073-97-3.gif)
14073-97-3
269 suppliers
$14.00/1g
![MENTHOL](/CAS/GIF/15356-70-4.gif)
15356-70-4
215 suppliers
$30.00/20mg
![L-MENTHONE](/CAS/GIF/14073-97-3.gif)
14073-97-3
269 suppliers
$14.00/1g
![DL-Menthol](/CAS/GIF/89-78-1.gif)
89-78-1
690 suppliers
$9.00/25g
![L-MENTHONE](/CAS/GIF/14073-97-3.gif)
14073-97-3
269 suppliers
$14.00/1g
![Cyclohexanone, 5-methyl-2-(1-methylethyl)-, oxime, (2S,5R)-](/CAS/20210305/GIF/65620-72-6.gif)
65620-72-6
0 suppliers
inquiry
![L-MENTHONE](/CAS/GIF/14073-97-3.gif)
14073-97-3
269 suppliers
$14.00/1g
![(1R,2R,5R)-2-ISOPROPYL-5-METHYLCYCLOHEXANAMINE](/CAS/GIF/16934-77-3.gif)
16934-77-3
10 suppliers
inquiry
![L-MENTHYLAMINE](/CAS/GIF/2216-54-8.gif)
2216-54-8
13 suppliers
inquiry
![Neomenthylamine](/CAS/GIF/7231-40-5.gif)
7231-40-5
2 suppliers
inquiry
![Cyclohexanamine, 5-methyl-2-(1-methylethyl)-, [1S-(1alpha,2ba,5ba)]- (9CI)](/CAS/GIF/160399-90-6.gif)
160399-90-6
1 suppliers
inquiry
![(+)-isomenthone](/CAS/GIF/1196-31-2.gif)
1196-31-2
33 suppliers
$175.00/100mg