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ChemicalBook CAS DataBase List L-Methionine [S]-Sulfoximine

L-Methionine [S]-Sulfoximine synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 4 steps
1: 1.5 hr, 0 deg C; 15 hr, room temp.
2: (CH3CO)2O / 6 h / Ambient temperature; Alternatively DCC, 3 hr, 0 deg C; 9 hr, room temp., pH 3 may also be used.
3: pyridine / Heating
4: hydrolysis and deblocking

References:

Sugiyama, Yuichi;Wedler, Frederick C. [Tetrahedron Letters,1983,vol. 24,# 14,p. 1471 - 1474]