L-Ornithine L-aspartate salt synthesis
- Product Name:L-Ornithine L-aspartate salt
- CAS Number:3230-94-2
- Molecular formula:C5H12N2O2.C4H7NO4
- Molecular Weight:265.26
Yield:3230-94-2 115 g
Reaction Conditions:
with zinc(II) chloride; pH=8.3 at 35 - 40; for 1.5 h;Reagent/catalyst;Temperature;pH-value;
Steps:
1-3; 1; 2 Example 1
Dissolve 100 g of L-arginine in 800 ml of water, adjust the temperature to 35-40 ° C, add aspartic acid to adjust the pH to 8.3, add 0.2 g of zinc chloride, 20 g of immobilized arginase in sequence, and react 1.5 Hours, 0.1% arginine residue in the reaction solution was monitored by HPLC (see Table 1 for purity of lactam in the reaction solution), filtered, aspartic acid was added to the filtrate to adjust the pH to 6.9, and concentrated to about 400 mL under reduced pressure. 800 mL of methanol was added at 75 ° C and crystallized to obtain a crude aspartic acid ornithine.Add 300 mL of water to the crude aspartic acid ornithine, stir to dissolve, add 4 g of activated carbon, stir and filter, and add 900 mL of methanol at 70-75 ° C to crystallize, grow for 30 minutes, drop to normal temperature, filter, and Aspartic acid ornithine products
References:
Hebei Yipin Pharmaceutical Co., Ltd.;Zhang Ji;Jia Zongying;Zhao Cuiran;Bai Shanshan;Li Lu;Zhang Xiaocai;Zhang Yongran;Zhang Xiaoqian CN110627671, 2019, A Location in patent:Paragraph 0034-0053
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