L-Proline, 5-oxo-, phenylmethyl ester synthesis
- Product Name:L-Proline, 5-oxo-, phenylmethyl ester
- CAS Number:94885-52-6
- Molecular formula:C12H13NO3
- Molecular Weight:219.24
Yield:94885-52-6 100%
Reaction Conditions:
with triethylamine in 1,2-dichloro-ethane at 60; for 15 h;Large scale;Temperature;
Steps:
2 Example 2
200 kg of 1,2-dichloroethane, 64.55 kg of L-pyroglutamic acid and 63.25 kg of triethylamine, put into a 500L reactor, the reaction solution was stirred while cooling, temperature controlled at 20 deg. C then dropwise addition of benzyl chloride 75.95kg. After dropwise addition was warmed to 60 deg. C, reaction 15h, TLC detected starting material consumption to indicate reaction completion. The reaction solution was cooled to 20 to 30 ° C, was added 100kg water, washed once, liquid separation, the organic layer was washed with 100 kg of saturated brine, the organic layer 1,2-dichloroethane solution was dried with sodium sulfate, filter, the filtrate was concentrated to produce brown yellow L-pyroglutamic acid benzyl ester 21.92 kg; molar yield 100%, the purity of the liquid was 97.10%.
References:
CN105732454,2016,A Location in patent:Paragraph 0024
71389-33-8
0 suppliers
inquiry
94885-52-6
23 suppliers
inquiry
113400-36-5
170 suppliers
$6.00/10g
94885-52-6
23 suppliers
inquiry