L-SEPIAPTERIN synthesis

Yield:-

Steps:

Multi-step reaction with 3 steps
1.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / acetonitrile / 1 h / 60 °C / Inert atmosphere; Molecular sieve
2.1: hydrogenchloride / methanol; water / 3 h / 50 °C
2.2: pH 7
3.1: hydrogen; Pd/C (Ph₂S); triethylamine / methanol; water / 3 h / 40 °C

References:

Shiratori Pharmaceutical Co., Ltd.;YOSHINO, Hiroshi;KOMODA, Taichi;SHIRO, Yuichi;MURATA, Shunichi;MURATA, Shizuaki;KURODA, Yasuhiro EP2848619, 2015, A1