ChemicalBook CAS DataBase List L(-)-Thiazolidine-4-carboxylic acid

L(-)-Thiazolidine-4-carboxylic acid synthesis

7synthesis methods

Product Name:L(-)-Thiazolidine-4-carboxylic acid
CAS Number:34592-47-7
Molecular formula:C4H7NO2S
Molecular Weight:133.17

50-00-0 Synthesis

50-00-0
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52-90-4 Synthesis

52-90-4
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34592-47-7
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Yield:34592-47-7 94%

Reaction Conditions:

in water at 0; for 4.5 h;

Steps:

7.I

To a stirred solution of 40% aq. formaldehyde (40 mL) at 0°C was added in portions solid L-cystein (12.1 g, 0.1 mol) over a period of 30 minutes. The reaction mixture was stirred for 4 h, after which the reaction mixture was filtered through a sintered funnel. The solids were washed with absolute ethanol then with diethyl ether. The solids were dried under high vacuum to obtain (4/?)-l,3-thiazolidine-4-carboxylic acid (12.5 g) in 94% yield. M.R, 215-217°C; m/z (M+l) 134; IR cm^"1 3429, 3049, 2357, 1629, 1463, 1383, 1343, 1014, 862; ¹H NMR (D₂O) 300 MHz δ 4.40-4.30 (m, 2H), 4.30-4.22 (m, IH), 3.40-3.18 (m, 2H).

References:

WO2007/113634,2007,A1 Location in patent:Page/Page column 64-65

50-00-0 Synthesis

50-00-0
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52-89-1 Synthesis