![](/CAS2/GIF/1062368-24-4.gif)
LDN-193189 synthesis
- Product Name:LDN-193189
- CAS Number:1062368-24-4
- Molecular formula:C25H22N6
- Molecular Weight:406.48
![4-Quinolinecarboxaldehyde](/CAS/GIF/4363-93-3.gif)
4363-93-3
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$7.00/250mg
![LDN-193189](/CAS2/GIF/1062368-24-4.gif)
1062368-24-4
161 suppliers
$35.00/1mg
Yield:-
Steps:
Multi-step reaction with 8 steps
1.1: methanol; sodium tetrahydroborate / 1.33 h / 0 - 20 °C
2.1: thionyl chloride / dichloromethane / 2.33 h / 0 - 20 °C
2.2: pH > 7 / Saturated solution
3.1: N,N-dimethyl-formamide / 20 - 80 °C
4.1: 6 h / 120 °C
5.1: hydrazine monohydrobromide / ethanol; water / 5 h / 110 °C
5.2: Saturated solution
6.1: acetic acid / ethanol / 0.08 h / 170 °C / Microwave irradiation
7.1: potassium tert-butylate / tris-(dibenzylideneacetone)dipalladium(0); johnphos / 1,1-dichloroethane / 20 h / 100 °C / Inert atmosphere
8.1: hydrogen / 5%-palladium/activated carbon / methanol; dichloromethane / 4 h / 20 °C / 760.05 Torr
References:
THE GENERAL HOSPITAL CORPORATION;THE BRIGHAM AND WOMEN'S HOSPITAL, INC. WO2009/114180, 2009, A1
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1000210-73-0
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![LDN-193189](/CAS2/GIF/1062368-24-4.gif)
1062368-24-4
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$35.00/1mg
![4-quinolylmethanol](/CAS/GIF/6281-32-9.gif)
6281-32-9
66 suppliers
$178.00/1g
![LDN-193189](/CAS2/GIF/1062368-24-4.gif)
1062368-24-4
161 suppliers
$35.00/1mg
![4-Chloromethylquinoline](/CAS/GIF/5632-17-7.gif)
5632-17-7
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$298.00/1g
![LDN-193189](/CAS2/GIF/1062368-24-4.gif)
1062368-24-4
161 suppliers
$35.00/1mg
![2-(quinolin-4-yl)acetonitrile](/CAS/GIF/14003-46-4.gif)
14003-46-4
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![LDN-193189](/CAS2/GIF/1062368-24-4.gif)
1062368-24-4
161 suppliers
$35.00/1mg