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ChemicalBook CAS DataBase List LEUKOTRIENE A3 METHYL ESTER

LEUKOTRIENE A3 METHYL ESTER synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: 83 percent / benzene / 1.5 h / 60 °C
2: 1.) n-butyllithium, 2.) Et3N, MsCl / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, -78 deg C, 1 h
3: tetrahydrofuran; hexamethylphosphoric acid triamide / 1 h / 0 °C

References:

Okuyama;Miyamoto;Shimoji;Konishi;Fukushima;Niwa;Arai;Toda;Hayashi [Chemical and Pharmaceutical Bulletin,1982,vol. 30,# 7,p. 2453 - 2462]

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