![](/CAS/GIF/73-78-9.gif)
Lidocaine hydrochloride synthesis
- Product Name:Lidocaine hydrochloride
- CAS Number:73-78-9
- Molecular formula:C14H23ClN2O
- Molecular Weight:270.8
![Lidocaine](/CAS/GIF/137-58-6.gif)
137-58-6
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$14.00/5g
![Lidocaine hydrochloride](/CAS/GIF/73-78-9.gif)
73-78-9
396 suppliers
$40.00/1g
Yield:73-78-9 100%
Reaction Conditions:
with hydrogenchloride in diethyl ether;
Steps:
Preparationof Lidocaine hydrochloride monohydrate:
Dry HCl was bubbled through a solution of lidocaine (3 g) in anhydrous ether (75 cm3). The salt precipitated immediately; passage of HCl continued until no further precipitate was formed.The salt was filtered and washed with liberal excess of ether to obtain it in almost quantitative yield. A portion of the salt was kept in the open atmosphere (72 h, next to a beaker containingwater as source of moisture) to obtain Lidocaine.HCl.H2O (mp is 73-74 °C in excellent agreement with literature reported mp of 73-74°C [1]). Another portion was dried under vacuum at 50°C until the mp of the salt reaches aconstant value indicating the formation of the anhydrous salt Lidocaine.HCl (closed capillary mp is 131-133°C, as compared to Lit. [2] mp of 127-132°C) for NMR spectral comparison.
References:
Badawi, Hassan M.;F?rner, Wolfgang;Ali, Shaikh A. [Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy,2016,vol. 152,p. 92 - 100] Location in patent:supporting information
![Diethylamine](/CAS/GIF/109-89-7.gif)
109-89-7
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![Chloroacetyl chloride](/CAS/GIF/79-04-9.gif)
79-04-9
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![2,6-Dimethylaniline](/CAS/GIF/87-62-7.gif)
87-62-7
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![Lidocaine hydrochloride](/CAS/GIF/73-78-9.gif)
73-78-9
396 suppliers
$40.00/1g
![2,6-Dimethylaniline](/CAS/GIF/87-62-7.gif)
87-62-7
453 suppliers
$10.00/5G
![Lidocaine hydrochloride](/CAS/GIF/73-78-9.gif)
73-78-9
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$40.00/1g
![2,6-Dimethylphenol](/CAS/GIF/576-26-1.gif)
576-26-1
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![Lidocaine hydrochloride](/CAS/GIF/73-78-9.gif)
73-78-9
396 suppliers
$40.00/1g