LIK066 synthesis
- Product Name:LIK066
- CAS Number:1291094-73-9
- Molecular formula:C23H28O7
- Molecular Weight:416.47
25252-00-0
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Yield:-
Steps:
Multi-step reaction with 8 steps
1.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 0 - 20 °C
2.1: aluminum (III) chloride / dichloromethane / 0 - 20 °C
3.1: trifluoroacetic acid; trifluorormethanesulfonic acid; triethylsilane / 0.42 h / 20 °C
4.1: n-butyllithium / toluene; hexane; tetrahydrofuran / 1 h / -78 °C
4.2: 1 h / -78 °C
4.3: 16 h / 20 °C
5.1: boron trifluoride diethyl etherate; triethylsilane / dichloromethane; acetonitrile / 4 h / 10 °C
6.1: dmap; pyridine / dichloromethane / 2 h / 20 °C
7.1: tricyclohexylphosphine; potassium phosphate / toluene; water / 0.75 h
7.2: Reflux
8.1: lithium hydroxide monohydrate / water; tetrahydrofuran; methanol
References:
NOVARTIS AG US2012/264700, 2012, A1
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