ChemicalBook CAS DataBase List Linzagolix

Linzagolix synthesis

6synthesis methods

Product Name:Linzagolix
CAS Number:935283-04-8
Molecular formula:C22H15F3N2O7S
Molecular Weight:508.42

773871-99-1
27 suppliers
$60.00/50mg

935283-04-8
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Yield:-

Steps:

Multi-step reaction with 6 steps
1: hydrogenchloride / toluene; water / 5 h / 38 - 43 °C
2: sodium hydroxide; tetrabutylammomium bromide / toluene; water / 4 h / 60 - 63 °C
3: acetic acid; nitric acid / 2 h / 59 - 62 °C
4: hydrogen / ethyl acetate / 4 h / 20 °C
5: triethylamine / tetrahydrofuran / 24 h / 20 °C
6: lithium hydroxide / tetrahydrofuran; methanol; water / 1.5 h / 11 - 13 °C

References:

CD: Kissei Pharmaceutical Co., Ltd.;Aiuchi Takayuki;Kasai Kiyoshi;Bei Kubo Shigeru;Ono Kosuke;Sonehara Jun'ichi;Kobayashi Makoto JP6268093, 2018, B2

187543-87-9 Synthesis

187543-87-9
144 suppliers
$25.00/250mg

935283-04-8
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References

Benzene, 2-(chloromethyl)-3,4-difluoro-1-methoxy-

1073435-67-2
16 suppliers
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935283-04-8
33 suppliers
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References

Benzene, 1,2-difluoro-3-[(4-fluoro-2-methoxyphenoxy)methyl]-4-methoxy-

1073435-69-4
1 suppliers
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935283-04-8
33 suppliers
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References

Benzene, 1,2-difluoro-3-[(4-fluoro-2-methoxy-5-nitrophenoxy)methyl]-4-methoxy-

1073435-71-8
8 suppliers
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935283-04-8
33 suppliers
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References