LITHIUM DIFLUOROACETATE synthesis

Yield:74956-94-8 88%

Reaction Conditions:

with lithium hydroxide monohydrate at 20;

Steps:

1; 2 Example 1 (Production of Compound F)

Ethyl difluoroacetate (100 g, 0.8065 mol) was added to the reactor, and the mixture was stirred at room temperature.Lithium hydroxide (17.4 g, 0.7258 mol) was added in portions and stirred at room temperature until the reaction was complete.After completion of the reaction, the liquid medium was distilled off from the reaction mixture under reduced pressure to obtain Compound F (lithium difluoroacetate) (64.9 g, 88% yield) (water content: 2340 ppm) as a fluorine-containing carboxylate compound.

References:

WO2022/54737,2022,A1 Location in patent:Paragraph 0775-0777