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ChemicalBook CAS DataBase List LNEHHTWYEBGHBY-VWYCJHECSA-N
157967-06-1

LNEHHTWYEBGHBY-VWYCJHECSA-N synthesis

7synthesis methods
69610-40-8 Synthesis
BOC-L-Prolinol

69610-40-8
389 suppliers
$6.00/5g

LNEHHTWYEBGHBY-VWYCJHECSA-N

157967-06-1
4 suppliers
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Yield:-

Steps:

Multi-step reaction with 4 steps
1: 87 percent / SO3*pyridine, Et3N / dimethylsulfoxide / 2.5 h / 7 - 8 °C
2: 1.) i-Pr2N, n-BuLi, MgBr2*Et2O / 1.) THF, hexane, -78 deg C, 30 min; -78 deg C to r.t., 2 h; -78 deg C, 1 h, 2.) THF, -95 deg C, 2 h
3: 72 percent / proton sponge / CH2Cl2 / 36 h / Ambient temperature
4: 86 percent / H2 / 10percent Pd/C / methanol / 15 h / Ambient temperature

References:

Pettit, George R.;Singh, Sheo Bux;Herald, Delbert L.;Lloyd-Williams, Paul;Kantoci, Darko;et al. [Journal of Organic Chemistry,1994,vol. 59,# 21,p. 6287 - 6295]