Lomerizine hydrochloride synthesis
- Product Name:Lomerizine hydrochloride
- CAS Number:101477-54-7
- Molecular formula:C27H32Cl2F2N2O3
- Molecular Weight:541.46
27064-94-4
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$24.00/5 g
5011-34-7
105 suppliers
$252.00/500mg
101477-54-7
202 suppliers
$26.00/100mg
Yield: 87.4%
Reaction Conditions:
Stage #1:4,4'-difluorobenzhydryl chloride;1-(2,3,4-trimethoxybenzyl)piperazine with triethylamine in methanol at 65 - 75; for 10 h;
Stage #2: with hydrogenchloride in ethanol at 45; for 2 h;
Steps:
1; 3
1-(2,3,4-Trimethoxybenzyl)piperazine (24.0 g, 0.09 mol) was dissolved in 200 mL of methanol then 4,4'-difluorodiphenylmethyl chloride (21.5 g, 0.09 mol) ) and triethylamine (18.2g, 0.18mol), under the condition of 65 °C ~ 75 °C tirred 10H, then cooled to 40 °C ~ 50 °C, temperature 40 °C ~ 50 °C fractions were concentrated under reduced pressure to not give 1- (R-(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine crude.
References:
Chenxin Pharmaceutical Co., Ltd.;Zhang Lebo;Sun Shoufei;Zhang Baikun;Li Zhongjing;Jiang Ruiling CN109666008, 2019, A Location in patent:Paragraph 0016; 0018; 0022; 0024; 0030; 0031
1133-49-9
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8013-43-2
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27469-60-9
273 suppliers
$8.00/1g
101477-54-7
202 suppliers
$26.00/100mg
27469-60-9
273 suppliers
$8.00/1g
2103-57-3
499 suppliers
$9.00/10g
101477-54-7
202 suppliers
$26.00/100mg