![](/CAS/20211123/GIF/1223405-08-0.gif)
Larotrectinib Sulfate synthesis
- Product Name:Larotrectinib Sulfate
- CAS Number:1223405-08-0
- Molecular formula:C21H24F2N6O6S
- Molecular Weight:526.52
![LOXO-101](/CAS/20180713/GIF/1223403-58-4.gif)
1223403-58-4
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$30.00/5MG
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1223405-08-0
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Yield:1223405-08-0 98.43%
Reaction Conditions:
with sulfuric acid in methanol at 20; for 0.5 h;Inert atmosphere;Solvent;Concentration;Temperature;
Steps:
3 Preparation of Amorphous Form AM(HS)
10422] To a solution of (S)-N-(5-((R)-2-(2,5-difluoro- phenyl)pyrrolidin-i -yl)pyrazolo[ 1 ,5-a]pyrimidin-3-yl)-3- hydroxypyrrolidine-i-carboxamide (9.40 g, 21.94 mmol) in MeOH (220 mE) was slowly added sulfuric acid (0.1 M in MeOH, 219.4 mE, 21.94 mmol) at ambient temperature under rapid stirring. Afier 30 minutes, the reaction was first concentrated by rotary evaporator to near dryness, then on high vacuum for 48 h to provide amorphous form of (S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin- 1 -yl)pyrazolo[ 1 ,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-i -carboxamide sulfate (11.37 g, 21.59 mmol, 98.43% yield). ECMS (apci mlz 429.1, M+H).
References:
US2017/281632,2017,A1 Location in patent:Paragraph 0382; 0419; 0420; 0421; 0422
![(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-amine](/CAS/20180529/GIF/1223404-88-3.gif)
1223404-88-3
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![(S)-3-Hydroxypyrrolidine hydrochloride](/CAS/GIF/122536-94-1.gif)
122536-94-1
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$7.00/5g
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1223405-08-0
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![5-Chloro-3-nitropyrazolo[1,5-a]pyriMidine](/CAS/GIF/1363380-51-1.gif)
1363380-51-1
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$7.00/100mg
![Larotrectinib Sulfate](/CAS/20211123/GIF/1223405-08-0.gif)
1223405-08-0
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![(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-nitropyrazolo[1,5-a]pyrimidine](/CAS/20180601/GIF/1223404-90-7.gif)
1223404-90-7
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![Larotrectinib Sulfate](/CAS/20211123/GIF/1223405-08-0.gif)
1223405-08-0
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![(2R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE](/StructureFile/ChemBookStructure9/GIF/CB8277099.gif)
1218935-59-1
152 suppliers
$115.00/250MG
![Larotrectinib Sulfate](/CAS/20211123/GIF/1223405-08-0.gif)
1223405-08-0
156 suppliers
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