m-Tolylsulfanyl-acetic acid ethyl ester synthesis
- Product Name:m-Tolylsulfanyl-acetic acid ethyl ester
- CAS Number:14738-26-2
- Molecular formula:C11H14O2S
- Molecular Weight:210.2927
Yield:-
Reaction Conditions:
with triethylamine in tetrahydrofuran at 20; for 4 h;
Steps:
2.3 Preparation of ethyl (phenylthio) acetates (6)
General procedure: A solution of thiophenol (0.10 mL, 0.977 mmol), and ethyl bromoacetate (0.164 g, 1.07 mmol) inTHF (13 mL) was treated with Et3N (0.17 mL, 1.17 mmol), stirred at room temperature for 4 h, anddiluted with Et2O and saturated. aqueous NaHCO3. The aqueous layer was extracted with Et2O. Thecombined organic layers were dried (MgSO4), filtered and concentrated in vacuo to give ethyl(phenylthio) acetate.
References:
Wang, Yuerong;Jia, Pengfei;Hao, Yingdi;Li, Jianglian;Lai, Ruizhi;Guo, Li;Wu, Yong [Tetrahedron Letters,2022,vol. 107,art. no. 154098] Location in patent:supporting information
