![](/CAS/GIF/790299-79-5.gif)
Masitinib synthesis
- Product Name:Masitinib
- CAS Number:790299-79-5
- Molecular formula:C28H30N6OS
- Molecular Weight:498.64
![4-Methyl-n3-(4-pyridin-3-yl-thiazol-2-yl)-benzene-1,3-diaMine](/CAS/GIF/660837-08-1.gif)
660837-08-1
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![METHYL 4-[(4-METHYLPIPERAZIN-1-YL)METHYL]BENZOATE](/CAS/GIF/314268-40-1.gif)
314268-40-1
79 suppliers
$90.00/500mg
![Masitinib](/CAS/GIF/790299-79-5.gif)
790299-79-5
236 suppliers
$29.00/10mg
Yield:790299-79-5 78%
Reaction Conditions:
Stage #1: N1-[4-(pyridin-3-yl)-1,3-thiazol-2-yl]-6-methyl-1,3-phenylenediaminewith trimethylaluminum in hexane;dichloromethane at 5 - 15; for 2 h;
Stage #2: 4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester in hexane;dichloromethane at 20; for 21.1667 h;Heating / reflux;
Stage #3: with sodium hydroxide;water in hexane;dichloromethane at 20; for 3 h;Product distribution / selectivity;
Steps:
4.A
Method A In a reactor and under low nitrogen pressure, add 4-Methyl-N3-(4-pyridin-3-yl-thiazol- 2-yl)-benzene-l,3-diamine (95 g, 336.45 mmol), dichloromethane (2 L). To this
References:
WO2008/98949,2008,A2 Location in patent:Page/Page column 20-21
![4-Methyl-n3-(4-pyridin-3-yl-thiazol-2-yl)-benzene-1,3-diaMine](/CAS/GIF/660837-08-1.gif)
660837-08-1
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![4-(4-Methylpiperazin-1-ylmethyl)benzoyl chloride](/CAS/GIF/148077-69-4.gif)
148077-69-4
74 suppliers
$680.00/250mg
![Masitinib](/CAS/GIF/790299-79-5.gif)
790299-79-5
236 suppliers
$29.00/10mg
![4-Methyl-n3-(4-pyridin-3-yl-thiazol-2-yl)-benzene-1,3-diaMine](/CAS/GIF/660837-08-1.gif)
660837-08-1
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![4-(4-Methylpiperazin-1-ylmethyl)benzoic acid](/CAS/GIF/106261-48-7.gif)
106261-48-7
189 suppliers
$17.67/5gm:
![Masitinib](/CAS/GIF/790299-79-5.gif)
790299-79-5
236 suppliers
$29.00/10mg
![3-Acetylpyridine](/CAS/GIF/350-03-8.gif)
350-03-8
642 suppliers
$10.00/5g
![Masitinib](/CAS/GIF/790299-79-5.gif)
790299-79-5
236 suppliers
$29.00/10mg
![tert-butyl (4-methyl-3-thioureidophenyl)carbamate](/CAS/20180601/GIF/660838-06-2.gif)
660838-06-2
1 suppliers
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![Masitinib](/CAS/GIF/790299-79-5.gif)
790299-79-5
236 suppliers
$29.00/10mg