ChemicalBook CAS DataBase List Maxacalcitol

Maxacalcitol synthesis

9synthesis methods

Product Name:Maxacalcitol
CAS Number:103909-75-7
Molecular formula:C26H42O4
Molecular Weight:418.61

917-54-4
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Propanoic acid, 3-[(1S)-1-[(1S,3aS,4E,7aS)-4-[(2Z)-[(3S,5R)-3,5-bis[[(1,1-diMethylethyl)diMethylsilyl]oxy]-2-Methylenecyclohexylidene]ethylidene]octahydro-7a-Methyl-1H-inden-1-yl]ethoxy]-, ethyl este

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103909-75-7
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Yield:103909-75-7 77%

Reaction Conditions:

Stage #1: methyllithium;3-((S)-1-{(1S,3aS,7aS)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-ethoxy)-propionic acid ethyl ester in tetrahydrofuran at -78; for 1 h;
Stage #2: with tetrabutyl ammonium fluoride in tetrahydrofuran at 20;

References:

Fall, Yagamare;González, Victoria;Vidal, Beatriz;Mouri?o, Antonio [Tetrahedron Letters,2002,vol. 43,# 3,p. 427 - 429]