ChemicalBook CAS DataBase List Meptazinol hydrochloride

Meptazinol hydrochloride synthesis

8synthesis methods

Product Name:Meptazinol hydrochloride
CAS Number:59263-76-2
Molecular formula:C15H24ClNO
Molecular Weight:269.81

2556-73-2
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59263-76-2
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Yield:-

Steps:

Multi-step reaction with 6 steps
1: 1.) butyl lithium, diisopropylamine / 1.) hexane/THF, 0 to -10 deg C, 10 min, 2.) THF, amb. temp., 1.5 h
2: 88 percent / bromine / CH₂Cl₂ / 1 h / 30 °C
3: 90 percent / aq. sodium hydroxide / Ambient temperature
4: 1.) sodium amide / 1.) toluene, reflux, 2 h, 2.) THF, 2 h
5: 84 percent / lithium aluminium hydride / tetrahydrofuran / 2 h / Heating
6: 92 percent / 12 M hydrochloric acid / 48 h / Heating

References:

Bradley;Cavalla;Edington;et al. [European Journal of Medicinal Chemistry,1980,vol. 15,# 4,p. 375 - 385]