Methyl 1-(aminomethyl)cyclopropanecarboxylate HCl synthesis

2synthesis methods

Product Name:Methyl 1-(aminomethyl)cyclopropanecarboxylate HCl
CAS Number:1170782-90-7
Molecular formula:C6H12ClNO2
Molecular Weight:165.62

67-56-1 Synthesis

67-56-1
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1-(aminomethyl)cyclopropanecarboxylic acid hydrochloride

1421601-23-1
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Methyl 1-(aminomethyl)cyclopropanecarboxylate HCl

1170782-90-7
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Yield:1170782-90-7 98%

Reaction Conditions:

with thionyl chloride in methanol at 20; for 3 h;

Steps:

P.2 Preparation of 1-(aminomethyl)-cyclopropylcarboxylic acid methylester hydrochloride
Preparational Example 2
Preparation of 1-(aminomethyl)-cyclopropylcarboxylic acid methylester hydrochloride
273 mg (1.8 mmol) of the 1-(aminomethyl)-cyclopropylacetic acid hydrochloride prepared in Preparational Example 1 was dissolved in 6 ml of methanol, to which 0.26 ml (3.6 mmol) of thionyl chloride was added, followed by stirring at room temperature for 3 hours.
Upon completion of the reaction, the solvent was evaporated under reduced pressure to give 291 mg of 1-(aminomethyl)-cyclopropylcarboxylic acid methylester hydrochloride (yield: 98%).
¹H NMR (400 MHz, D₂O) δ 3.60 (s, 3H), 3.06 (s, 2H), 1.28-1.31 (m, 2H), 0.97-0.99 (m, 2H)

References:

Ahn, Soon Kil;Auh, Jin;Choi, Nam Song;Han, Chang Kyun;Kim, Tae-Jeong;Pae, Kamsa;Shin, Young June;Han, Dong-Oh;Han, Cheol Kyu US2015/210635, 2015, A1 Location in patent:Paragraph 0412-0414

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Cyclopropanecarboxylic acid, 1-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-, methyl ester

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1170782-90-7
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References