methyl 1-benzyl-1H-indole-2-carboxylate synthesis
- Product Name:methyl 1-benzyl-1H-indole-2-carboxylate
- CAS Number:81787-92-0
- Molecular formula:C17H15NO2
- Molecular Weight:265.31
Yield:81787-92-0 99.3%
Reaction Conditions:
Stage #1: indole-2-carboxylic acid methyl esterwith sodium hydride in N,N-dimethyl-formamide at 20; for 1 h;Metallation;
Stage #2: benzyl bromide in N,N-dimethyl-formamide at 20; for 5 h;Alkylation;
References:
Kitano, Masafumi;Kojima, Atsuyuki;Nakano, Kazuhiro;Miyagishi, Akira;Noguchi, Tsuyoshi;Ohashi, Naohito [Chemical and Pharmaceutical Bulletin,1999,vol. 47,# 11,p. 1538 - 1548]
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