Methyl 1-phenylcyclopropanecarboxylate synthesis

9synthesis methods

Product Name:Methyl 1-phenylcyclopropanecarboxylate
CAS Number:6121-42-2
Molecular formula:C11H12O2
Molecular Weight:176.21

67-56-1 Synthesis

67-56-1
739 suppliers
$9.00/25ml

6120-95-2 Synthesis

6120-95-2
161 suppliers
$7.00/250mg

6121-42-2
32 suppliers
$108.75/250mg

Yield:6121-42-2 97%

Reaction Conditions:

with hydrogenchloride in 1,4-dioxane at 50; for 20 h;

Steps:

1a.1 methyl I -phenylcyclopropanecarboxylate

Step 1: 1 -phenyl-1 -cyclopropanecarboxylic acid (10.0 g, 61 .66 mmol) was dissolved in MeOH (150 mL). 4 M HCI in dioxane (10 mL)was added and the mixture was heated to 50°C for 20h. The reaction mixture was concentrated todryness. EtOAc and sat. NaHCO3 solution was added and the two phases werepartitionated. The organic layer was dried over Mg504, filtered and the solution concentrated to dryness to afford methyl 1-phenylcyclopropanecarboxylate Ex.29a (10.55 g, 97%) as colourless oil. The compound was pure enough andused in the next step without further purification.

References:

WO2018/138359,2018,A1 Location in patent:Page/Page column 41; 52

6120-95-2 Synthesis

6120-95-2
161 suppliers
$7.00/250mg

6121-42-2
32 suppliers
$108.75/250mg

References