METHYL 1-(PHENYLSULFONYL)-1H-INDOLE-2-CARBOXYLATE synthesis
- Product Name:METHYL 1-(PHENYLSULFONYL)-1H-INDOLE-2-CARBOXYLATE
- CAS Number:60376-48-9
- Molecular formula:C16H13NO4S
- Molecular Weight:315.34
Yield:60376-48-9 605 mg
Reaction Conditions:
with sodium hydride in N,N-dimethyl-formamide at 20; for 1 h;
Steps:
[0262] Synthesis of methyl l-(phenylsulfonyl)-lH-indole-2-carboxylate.
[0262] Synthesis of methyl l-(phenylsulfonyl)-lH-indole-2-carboxylate. To a solution of methyl lH-indole-2-carboxylate (350 mg, 2 mmol) in N,N-dimethylformamide (10 mL), was added sodium hydride (60%, 120 mg, 3.0 mmol), followed by addition of benzenesulfonyl chloride (0.26 mL, 2 mmol) at room temperature. After stirring for 1 hour, the reaction mixture was diluted with ethyl acetate (30 mL) and washed with brine (20 mL x 3). The organic layer was dried over anhydrous sodium sulfate, filtered, concentrated, and purified by silica gel chromatography (ethyl acetate:hexanes = 5:95 to 20:80) to afford 605 mg of the title compound as white solid
References:
WO2013/130703,2013,A2 Location in patent:Paragraph 0262
1477-50-5
503 suppliers
$6.00/5g
60376-48-9
7 suppliers
inquiry
40899-71-6
150 suppliers
$5.00/1g
60376-48-9
7 suppliers
inquiry