![](/CAS/GIF/394223-19-9.gif)
METHYL 1H-PYRROLO[3,2-B]PYRIDINE-2-CARBOXYLATE synthesis
- Product Name:METHYL 1H-PYRROLO[3,2-B]PYRIDINE-2-CARBOXYLATE
- CAS Number:394223-19-9
- Molecular formula:C9H8N2O2
- Molecular Weight:176.17
![Methanol](/CAS/GIF/67-56-1.gif)
67-56-1
736 suppliers
$7.29/5ml-f
![1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid ethyl ester](/CAS2/GIF/17288-32-3.gif)
17288-32-3
120 suppliers
$26.00/250mg
![METHYL 1H-PYRROLO[3,2-B]PYRIDINE-2-CARBOXYLATE](/CAS/GIF/394223-19-9.gif)
394223-19-9
52 suppliers
$195.00/250mg
Yield: 90%
Reaction Conditions:
with potassium carbonate at 55; for 1 h;
Steps:
Add to ethyl 4-azaindole-2-carboxylate 4a (42.3 mmol) in MeOH (50 mL), K2CO3 (1.20 equiv, 50.7 mmol) and stir the suspension with heating to 55° C. for 1 h. Monitor the reaction by tlc (Et2O/hept). When complete, concentrate the reaction in vacuo, dilute with H2O and stir for 15 min. Collect the solid by filtration and dry in a vacuum oven at 65° C. for 3 h to afford about 90% to about 100% of the desired methyl 4-azaindole-2-carboxylate 5a.
References:
Aventis Pharmaceuticals Inc. US2005/131012, 2005, A1 Location in patent:Page/Page column 15
![1H-PYRROLO[3,2-B]PYRIDINE-2-CARBOXYLIC ACID](/CAS/GIF/17288-35-6.gif)
17288-35-6
99 suppliers
$21.00/100mg
![(TRIMETHYLSILYL)DIAZOMETHANE](/CAS/GIF/18107-18-1.gif)
18107-18-1
206 suppliers
$33.00/5g
![METHYL 1H-PYRROLO[3,2-B]PYRIDINE-2-CARBOXYLATE](/CAS/GIF/394223-19-9.gif)
394223-19-9
52 suppliers
$195.00/250mg
![Methanol](/CAS/GIF/67-56-1.gif)
67-56-1
736 suppliers
$7.29/5ml-f
![1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid ethyl ester](/CAS2/GIF/17288-32-3.gif)
17288-32-3
120 suppliers
$26.00/250mg
![METHYL 1H-PYRROLO[3,2-B]PYRIDINE-2-CARBOXYLATE](/CAS/GIF/394223-19-9.gif)
394223-19-9
52 suppliers
$195.00/250mg
![1h-pyrrolo[3,2-b]pyridine-2-carboxaMide](/CAS/20150408/GIF/853685-35-5.gif)
853685-35-5
6 suppliers
inquiry
![1H-PYRROLO[3,2-B]PYRIDINE-2-CARBOXYLIC ACID](/CAS/GIF/17288-35-6.gif)
17288-35-6
99 suppliers
$21.00/100mg