Methyl 2-(1,2,3,4-tetrahydroquinolin-6-yl)acetate synthesis
- Product Name:Methyl 2-(1,2,3,4-tetrahydroquinolin-6-yl)acetate
- CAS Number:5622-50-4
- Molecular formula:C12H15NO2
- Molecular Weight:205.25
5622-36-6
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5622-50-4
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Yield:-
Reaction Conditions:
with palladium 10% on activated carbon;hydrogen in ethanol at 50; under 1551.49 Torr; for 12 h;
Steps:
35.1 Step 1. methyl 2-(1.2.3.4-tetrahvdroquinolin-6-yl)acetate
To a solution of methyl 2-(quinolin-6-yl)acetate (700 mg, 3.30 mmol) in ethanol (20 mL) was added Pd/C (400 mg, 0.376 mmol)(10%), and the reaction was stirred at 50 °C under 30 psi of hydrogen. The reaction was monitored by LCMS. After stirring for 12 h the reaction was finished. The catalyst was removed off by filtration, and the filtrate was concentrated in vacuo to give the title compound as an oil. LCMS m/z (M+H+) calc'd 206.1, found 206.0
References:
WO2019/89412,2019,A1 Location in patent:Page/Page column 74; 75
5622-49-1
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18107-18-1
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5622-50-4
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