methyl 2-(2-bromo-1,3-thiazol-5-yl)acetate synthesis

Yield: 39.8%

Reaction Conditions:

with tert.-butylnitrite;copper(ll) bromide in acetonitrile

Steps:

1 Step 1.
Methyl 2-(2-bromothiazol-5-yl)acetate (7)
Step 1.
Methyl 2-(2-bromothiazol-5-yl)acetate (7)
Title compound 7 was synthesized from the commercially available methyl 2-(2-aminothiazol-5-yl)acetate (6) by following a procedure similar to the one disclosed in WO 2006/114274 A1, in 39.8% yield. MS (m/z): 236.0 and 238.0 (M+H).

References:

METHYLGENE INC.;Raeppel, Franck;Raeppel, Stephane;Vaisburg, Arkadii US2014/81017, 2014, A1 Location in patent:Paragraph 0341