METHYL 2-(5-METHOXY-1H-INDOL-3-YL)-2-OXOACETATE synthesis
- Product Name:METHYL 2-(5-METHOXY-1H-INDOL-3-YL)-2-OXOACETATE
- CAS Number:99988-56-4
- Molecular formula:C12H11NO4
- Molecular Weight:233.22
67-56-1
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$9.00/25ml
1006-94-6
476 suppliers
$10.00/5g
79-37-8
463 suppliers
$17.67/10gm:
99988-56-4
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$165.00/0.5g
Yield:99988-56-4 98%
Reaction Conditions:
Stage #1: 5-methoxylindole;oxalyl dichloride in diethyl ether at 0; for 1.5 h;
Stage #2: methanol in diethyl ether at 0; for 1 h;
Steps:
1.1 Example 1
In the first step, add 5-methoxyindole (1.00g, 6.80mmol) and diethyl ether (14mL) into a 100mL round bottom flask, add oxalyl chloride (0.68mL) dropwise at 0C, react for 1.5h and filter with suction , The solid obtained by suction filtration was added to a 100mL round-bottomed flask, and MeOH (60mL) was added at 0°C, reacted for 1h and then suction filtered to obtain compound 29, a yellow solid, with a yield of 98%.
References:
CN113072553,2021,A Location in patent:Paragraph 0053; 0056-0058
1006-94-6
476 suppliers
$10.00/5g
79-37-8
463 suppliers
$17.67/10gm:
99988-56-4
23 suppliers
$165.00/0.5g
1006-94-6
476 suppliers
$10.00/5g
79-37-8
463 suppliers
$17.67/10gm:
124-41-4
682 suppliers
$12.00/25g
99988-56-4
23 suppliers
$165.00/0.5g
1006-94-6
476 suppliers
$10.00/5g
99988-56-4
23 suppliers
$165.00/0.5g