ChemicalBook CAS DataBase List Methyl 2,6-dichloro-4-cyanobenzoate

Methyl 2,6-dichloro-4-cyanobenzoate synthesis

5synthesis methods

Product Name:Methyl 2,6-dichloro-4-cyanobenzoate
CAS Number:409127-32-8
Molecular formula:C9H5Cl2NO2
Molecular Weight:230.05

409127-31-7
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409127-32-8
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Yield:409127-32-8 88%

Reaction Conditions:

with pyridine;trifluoroacetic anhydride at 0 - 20; for 1 h;

Steps:

Step a: Synthesis of methyl 2,6-dichloro-4-cyanobenzoateTo a solution of methyl 4-carbamoyl-2,6-dichlorobenzoate (100 mg, 0.4 mmol) in pyridine (2 mL) trifluoro-acetic anhydride (0.1 1 ml, 0.8 mmol) was added drop wise at 0 °C. The reaction mixture was allowed to warm to room temperature and stirred for 1 hour. The contents were poured into ice cold water and the precipitated solid was filtered, washed with water and dried to yield methyl 2,6-dichloro-4- cyanobenzoate (55 mg, 88%) as an off-white solid.

References:

WO2012/160464,2012,A1 Location in patent:Page/Page column 77-78

5372-81-6 Synthesis