methyl 2-acetylpent-4-en-1-oate synthesis

11synthesis methods

Product Name:methyl 2-acetylpent-4-en-1-oate
CAS Number:3897-04-9
Molecular formula:C8H12O3
Molecular Weight:156.18

105-45-3
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106-95-6 Synthesis

106-95-6
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3897-04-9
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Yield:3897-04-9 96%

Reaction Conditions:

with potassium carbonate in acetonitrile at 20; for 6 h;Tsuji-Trost Allylation;Reagent/catalyst;

Steps:

4.2 General Procedure for the Allylation/Cinnamylation of 1,3-Dicarbonyl CompoundsUsing MMZ_NiY Zeolite

General procedure: A mixture of 1,3-dicarbonyls (1 mmol), allyl/cinnamyl bromide(2 mmol) and K2CO3(1 mmol) were added to the reactiontube, which contains acetonitrile (3 ml) and 100 mg of freshly activated MMZNiYzeolite. The reaction mixturewas stirred for 6 h. Products were extracted from the reactionmixture after the addition of 15 ml of dichloromethanesolvent and allowed for 2 h stirring again. The catalyst wasseparated from the reaction mixture by simple filtration.Then, the solvents were removed by evaporation in a rotaryevaporator. Proceedings of the reaction was constantly monitoredby TLC [silica gel, pet ether:ethyl acetate (8:2)]. Theproducts were purified by column Chromatography [usingpet ether (97%):ethyl acetate (3%)].

References:

Senthilkumar, Samuthirarajan;Thangapriya, Cheirmakani;Alagumurugayee, Raman;Kumarraja, Mayilvasagam [Catalysis Letters,2017,vol. 147,# 11,p. 2755 - 2763]

14418-84-9 Synthesis