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ChemicalBook CAS DataBase List Methyl 2-aMino-2-(3-chlorophenyl)acetate

Methyl 2-aMino-2-(3-chlorophenyl)acetate synthesis

1synthesis methods
-

Yield:-

Reaction Conditions:

with dichloro sulfoxide at 0 - 20; for 18.5 h;

Steps:

15

To amino(3-chlorophenyl)acetic acid (5.Og; 26.95mmol) suspended in methanol (30ml) and stirred at ice-bath temperature under argon was added dropwise thionyl chloride (30ml) over 30min. After stirring for a further 2h at 50C and at room temperature for 16h, the reaction solution was evaporated under reduced pressure. Trituration of the residue with diethylether afforded the title compound as a ca. 1 :1 mixture with amino(3- chlorophenyl)acetic acid (6.16g).

References:

WO2007/104775,2007,A1 Location in patent:Page/Page column 39-40

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