ChemicalBook CAS DataBase List methyl 2-amino-4,6-dimethoxybenzoate

methyl 2-amino-4,6-dimethoxybenzoate synthesis

5synthesis methods

Product Name:methyl 2-amino-4,6-dimethoxybenzoate
CAS Number:379228-26-9
Molecular formula:C10H13NO4
Molecular Weight:211.21

80-11-5 Synthesis

N-Methyl-N-nitrosotoluene-4-sulphonamide

80-11-5
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21577-57-1 Synthesis

21577-57-1
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379228-26-9
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Yield:-

Reaction Conditions:

with sodium hydroxide in ethanol;dichloromethane;

Steps:

1 Example 1

Using an analogous procedure to that described by Lombardi et al., Chemistry & Industry , 1990, 708, diazomethane was generated from a mixture of N -methyl-N -nitroso-4-toluenesulphonamide (31 g), ethanol (200 ml) and a saturated aqueous sodium hydroxide solution (35 ml) and bubbled though a solution of 2-amino-4,6-dimethoxybenzoic acid (15.9 g) in methylene chloride (280 ml) which had been cooled to 0°C. The resultant reaction mixture was evaporated and the residue was purified by column chromatography on silica using methylene chloride as eluent. There was thus obtained methyl 2-amino-4,6-dimethoxybenzoate (16.2 g); NMR Spectrum : (DMSOd₆) 3.65 (s, 3H), 3.7 (s, 6H), 5.75 (s, 1H), 5.9 (s, 1H), 6.2 (br s, 2H).

References:

EP1292594,2004,B1

21577-57-1 Synthesis

21577-57-1
112 suppliers
$20.00/250mg