Methyl 2-amino-5-hydroxy-4-methoxybenzoate synthesis
- Product Name:Methyl 2-amino-5-hydroxy-4-methoxybenzoate
- CAS Number:50413-44-0
- Molecular formula:C9H11NO4
- Molecular Weight:197.19
215659-03-3
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50413-44-0
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Yield: 93%
Reaction Conditions:
with hydrogen;palladium 10% on activated carbon in ethyl acetate for 4 h;
Steps:
10
Example 10: Preparation of Methyl-2-amino-5-hydroxy-4-methoxy benzoate (X); Ethyl acetate (300 ml), methyl-5-hydroxy-4-methoxy-2-nitro benzoate (50 gm) and 10% palladium/carbon (5 gm) were hydrogenated under a hydrogen gas pressure of 5-6 kg for 4 hours. The reaction mass was filtered to remove catalyst. The filtrate was distilled off to remove solvent. The residue obtained was stirred in n-hexane (100 ml) at 0-5°C The solid obtained was filtered and washed with n-hexane (25 ml) to yield the title compound (40 gm, 93% yield).
References:
CIPLA LIMITED;CURTIS, Philip, Anthony WO2008/125867, 2008, A2 Location in patent:Page/Page column 26
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