![](/CAS/GIF/872624-52-7.gif)
methyl 2-amino-5-iodo-4-(trifluoromethyl)benzoate synthesis
- Product Name:methyl 2-amino-5-iodo-4-(trifluoromethyl)benzoate
- CAS Number:872624-52-7
- Molecular formula:C9H7F3INO2
- Molecular Weight:345.06
![2-AMINO-4-TRIFLUOROMETHYL-BENZOIC ACID METHYL ESTER](/CAS/GIF/61500-87-6.gif)
61500-87-6
119 suppliers
$19.00/1g
![methyl 2-amino-5-iodo-4-(trifluoromethyl)benzoate](/CAS/GIF/872624-52-7.gif)
872624-52-7
51 suppliers
$15.00/100mg
Yield:872624-52-7 99%
Reaction Conditions:
with iodine;silver sulfate in ethanol at 20; for 2 h;Product distribution / selectivity;
Steps:
3.3
Step 3; Preparation of methyl 2-amino-5-iodo-4-trifluoromethylbenzoate; Add a solution of methyl 2-amino-4-trifluoromethylbenzoate (178 g, 812 mmol) inethanol (3.3 L) to a suspension of iodine (206.1 g, 812 mmol) and silver(II) sulfate (253g, 812 mmol) in ethanol (5 L) at room temperature under an atmosphere of nitrogen andstir for 2 h. Filter the suspension through a pad of a Celite, wash the pad withadditional ethanol (2 L) and remove the solvents from the combined filtrates underreduced pressure at 40 °C. Dissolve the residue in ethyl acetate (7.5 L) and wash withsaturated sodium bicarbonate solution (3 x 1.5 L), water (3 x 1.5 L) and brine (2 L). Drythe organic phase over anhydrous magnesium sulfate, filter and remove the solvent underreduced pressure to give the title compound as a pale brown crystalline solid (276.0 g,99%).
References:
WO2006/2342,2006,A1 Location in patent:Page/Page column 56
![2-AMINO-4-(TRIFLUOROMETHYL)BENZOIC ACID](/CAS/GIF/402-13-1.gif)
402-13-1
167 suppliers
$18.00/5g
![methyl 2-amino-5-iodo-4-(trifluoromethyl)benzoate](/CAS/GIF/872624-52-7.gif)
872624-52-7
51 suppliers
$15.00/100mg
![2-Nitro-4-trifluoromethylbenzoic acid](/CAS/GIF/320-94-5.gif)
320-94-5
229 suppliers
$9.00/1g
![methyl 2-amino-5-iodo-4-(trifluoromethyl)benzoate](/CAS/GIF/872624-52-7.gif)
872624-52-7
51 suppliers
$15.00/100mg