methyl 2-(benzylamino)acetate synthesis
- Product Name:methyl 2-(benzylamino)acetate
- CAS Number:17136-35-5
- Molecular formula:C10H14ClNO2
- Molecular Weight:215.68
67-56-1
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17136-36-6
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Yield: 99%
Reaction Conditions:
with hydrogenchloride in 1,4-dioxane
Steps:
9.1
Step 1 : Methyl 2-(benzylamino)acetate hydrochloride (27). To a N-benzyl glycine 26 (500 mg, 3.0 mmol) in MeOH (6 mL) was added 4M solution of HCl in dioxane (4 mL) and stirred overnight. The reaction mixture was concentrated to afford compound 27 (649mg, 99%) as a white solid. The crude compound was carried forward without further purification. LRMS (ESI): (calc) 179.2 (found) 180.1(MH)+.
References:
METHYLGENE INC. WO2008/122115, 2008, A1 Location in patent:Page/Page column 52
6436-90-4
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17136-35-5
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100-46-9
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17136-35-5
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