Methyl 2-bromo-4-fluoro-5-methoxybenzoate synthesis
- Product Name:Methyl 2-bromo-4-fluoro-5-methoxybenzoate
- CAS Number:1007455-22-2
- Molecular formula:C9H8BrFO3
- Molecular Weight:263.06
67-56-1
739 suppliers
$9.00/25ml
1007455-21-1
54 suppliers
$60.00/50mg
1007455-22-2
25 suppliers
$170.00/500mg
Yield:1007455-22-2 100%
Reaction Conditions:
with sulfuric acid for 7.5 h;Reflux;
Steps:
59 EXAMPLE 59 Methyl 2-bromo-4-fluoro-5-methoxybenzoate
A solution of 9-2 (1 g, 4.03 mmol) and 96% H2SO4 (0.65 mL, 13 mmol) in dry MeOH (15 mL) was refluxed for 7.5 h and cooled to rt. MeOH was evaporated and the residue taken up in DCM (15 mL), washed with saturated sodium bicarbonate (15 mL). The separated aqueous phase (final pH 7.5-8) was extracted with DCM (2×10 mL) and the organic phases were combined and washed with water (15 mL). The resulting organic phase was dried over sodium sulfate, concentrated to yield 9-3 as a solid (1.06 g, 100% yield). HPLC 98% pure.
References:
US2015/175540,2015,A1 Location in patent:Paragraph 0368; 0371; 0372
82846-18-2
166 suppliers
$6.00/250mg
1007455-22-2
25 suppliers
$170.00/500mg